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300 CE
400 CE
500 CE
600 CE
332 BCE: Alexander the Great conquers Phoenicia and turns toward Egypt.
331 BCE: Alexander the Great founds Alexandria at the port town of Rhakotis in Egypt.
323 BCE: Death of Alexander the Great.
305 BCE - 285 BCE: Reign of Ptolemy I in Egypt, who initiated the Great Library.
300 BCE - 280 BCE: The Lighthouse of Alexandria is built, one of the Seven Wonders of the Ancient World.
300 BCE: Ptolemy I founds the Museum of Alexandria.
282 BCE - 246 BCE: Reign of Ptolemy II in Egypt, development of Library at Alexandria.
276 BCE - 195 BCE: Life of Eratosthenes, ancient Greek Alexandrian scholar, native of Cyrene and one of the greatest geographers in antiquity.
247 BCE: The Lighthouse of Alexandria (Pharos) is completed.
48 BCE: Pompey killed at Alexandria, Caesar declares martial law in the city.
48 BCE - 44 BCE: Julius Caesar of Rome and Cleopatra VII of Egypt in unofficial alliance.
48 BCE: Caesar defeats Pompey (battle of Pharsalus); Pompey flees to Egypt and is killed by courtiers of Ptolemy XIII.
44 BCE: Assassination of Julius Caesar at Rome.
41 BCE - 31 BCE: Mark Antony of Rome allied with Cleopatra VII of Egypt.
34 BCE: Mark Antony celebrates an unofficial triumph in Alexandria following his victories in Armenia.
30 BCE: Death of Cleopatra VII, end of the Ptolemaic Dynasty in Egypt.
30 BCE - 14 CE: Reign of Augustus Caesar in Rome, restoration of Roman province of Alexandria.
100 CE: The mathematician and astronomer Menelaus of Alexandria lived.
115 CE: Destruction of Alexandria in the Kitos War.
117 CE: Restoration of Alexandria by Emperor Hadrian of Rome.
132 CE: Septuagint (Greek translation of the Bible) composed at Alexandria.
313 CE: Constantine the Great issues Edict of Milan, decrees religious tolerance.
314 CE: Religious strife increases between Christians and other faiths in Alexandria.
391 CE: Christian Patriarch Theophilus destroys pagan temples in Alexandria. .
415 CE: Hypatia of Alexandria murdered by Christian mob. Scholars and scientists leave the city. .
619 CE: Alexandria is conquered by the Sassanid Persians.
628 CE: Byzantine Empire re-takes Alexandria, Egypt, from the Persians.
641 CE: Arab Muslims under Caliph Umar take Alexandria from the Byzantine Christians.
641 CE - 646 CE: The Byzantine Christians and Arab Muslims fight for control of Alexandria and Egypt.
646 CE: The Arab Muslims defeat the Byzantine Christians. Alexandria falls under Islamic rule. .