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1450 CE
1460 CE
1470 CE
1480 CE
1490 CE
1453 CE: The Ottoman Empire closes the overland Silk Road trade routes between Europe and the East, initiating the European Age of Discovery.
1492 CE - 1493 CE: First Voyage of Christopher Columbus to the New World in three ships in an attempt to establish maritime trade routes to the East.
1493 CE - 1496 CE: Second Voyage of Christopher Columbus to the New World in 17 ships to colonize the region.